Chiral resolution and molecular modeling investigation of rac-2-cyclopentylthio-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydro-5-methylpyrimidin-4(3H)-one (MC-1047), a potent anti-HIV-1 reverse transcriptase agent of the DABO class.

@article{Quaglia2001ChiralRA,
  title={Chiral resolution and molecular modeling investigation of rac-2-cyclopentylthio-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydro-5-methylpyrimidin-4(3H)-one (MC-1047), a potent anti-HIV-1 reverse transcriptase agent of the DABO class.},
  author={M. Quaglia and A. Mai and G. Sbardella and M. Artico and R. Ragno and S. Massa and D. del Piano and G. Setzu and S. Doratiotto and V. Cotichini},
  journal={Chirality},
  year={2001},
  volume={13 2},
  pages={
          75-80
        }
}
  • M. Quaglia, A. Mai, +7 authors V. Cotichini
  • Published 2001
  • Chemistry, Medicine
  • Chirality
  • rac-2-Cyclopentylthio-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydro-5-methylpyrimidin-4(3H)-one (MC-1047) is a potent inhibitor of HIV-1 multiplication in acutely infected cells. MC-1047 racemate has been resolved by chiral HPLC using, as chiral stationary phase (CSP), a commercially available (R,R)-Whelk-01 column. The optical purity and the circular dichroism (CD) of the two resolved enantiomers were determined and their biological activities tested in in vitro assays. Molecular modeling… CONTINUE READING
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