Chiral primary-tertiary diamine catalysts derived from natural amino acids for syn-aldol reactions of hydroxy ketones.

Abstract

A series of primary-tertiary diamine catalysts were designed and synthesized from primary natural amino acids. Application of these new chiral catalysts in direct aldol reactions of alpha-hydroxyketones showed very good catalytic activity (up to 97% yield) and high syn selectivity (up to syn/ anti = 30:1, 99% ee).

DOI: 10.1021/jo802557p

Cite this paper

@article{Li2009ChiralPD, title={Chiral primary-tertiary diamine catalysts derived from natural amino acids for syn-aldol reactions of hydroxy ketones.}, author={Jiuyuan Li and Sanzhong Luo and Jin-Pei Cheng}, journal={The Journal of organic chemistry}, year={2009}, volume={74 4}, pages={1747-50} }