• DOI:10.1016/J.CHROMA.2006.07.077
Corpus ID: 1366695

Chiral high-performance liquid chromatographic separation and circular dichroism spectra of the enantiomers of cytotoxic aristocularine alkaloids.

@article{Caccamese2006ChiralHL,
  title={Chiral high-performance liquid chromatographic separation and circular dichroism spectra of the enantiomers of cytotoxic aristocularine alkaloids.},
  author={S. Caccamese and Giovanna Scivoli and Salvatore Bianca and J. M. L{\'o}pez-Romero and Francisco Javier Ortiz-L{\'o}pez},
  journal={Journal of chromatography. A},
  year={2006},
  volume={1129 1},
  pages={
          140-4
        }
}

S. Caccamese, Giovanna Scivoli, +2 authors Francisco Javier Ortiz-López

Published 2006

Chemistry, Medicine

Journal of chromatography. A

The HPLC enantiomeric separation of the racemic cularinoid alkaloids N-p-methoxy-1,alpha-dihydroaristoyagonine (1) and 4',5'-demethoxy-1,alpha-dihydroaristoyagonine (2) was accomplished using five chiral stationary phases (CSPs), some of them polysaccharide-derived ones. The molecular size and conjugative effect strongly affect the different enantioselectivity of the compounds 1 and 2 on the various CSPs investigated. Single enantiomers of 1 were isolated by repeated injections on an analytical… CONTINUE READING

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