Chiral high-performance liquid chromatographic separation and circular dichroism spectra of the enantiomers of cytotoxic aristocularine alkaloids.

@article{Caccamese2006ChiralHL,
  title={Chiral high-performance liquid chromatographic separation and circular dichroism spectra of the enantiomers of cytotoxic aristocularine alkaloids.},
  author={S. Caccamese and Giovanna Scivoli and Salvatore Bianca and J. M. L{\'o}pez-Romero and Francisco Javier Ortiz-L{\'o}pez},
  journal={Journal of chromatography. A},
  year={2006},
  volume={1129 1},
  pages={
          140-4
        }
}
  • S. Caccamese, Giovanna Scivoli, +2 authors Francisco Javier Ortiz-López
  • Published 2006
  • Chemistry, Medicine
  • Journal of chromatography. A
  • The HPLC enantiomeric separation of the racemic cularinoid alkaloids N-p-methoxy-1,alpha-dihydroaristoyagonine (1) and 4',5'-demethoxy-1,alpha-dihydroaristoyagonine (2) was accomplished using five chiral stationary phases (CSPs), some of them polysaccharide-derived ones. The molecular size and conjugative effect strongly affect the different enantioselectivity of the compounds 1 and 2 on the various CSPs investigated. Single enantiomers of 1 were isolated by repeated injections on an analytical… CONTINUE READING
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    SHOWING 1-10 OF 17 REFERENCES
    Polysaccharide Derivatives for Chromatographic Separation of Enantiomers.
    • 686
    Importance of stereospecific bioanalytical monitoring in drug development.
    • J. Caldwell
    • Chemistry, Medicine
    • Journal of chromatography. A
    • 1996
    • 109
    Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
    • T. Mosmann
    • Biology, Medicine
    • Journal of immunological methods
    • 1983
    • 43,767
    • PDF