Chiral drugs: comparison of the pharmacokinetics of [11C]d-threo and l-threo-methylphenidate in the human and baboon brain

@article{Ding1997ChiralDC,
  title={Chiral drugs: comparison of the pharmacokinetics of [11C]d-threo and l-threo-methylphenidate in the human and baboon brain},
  author={Y. Ding and J. Fowler and N. Volkow and S. Dewey and G. Wang and J. Logan and S. Gatley and N. Pappas},
  journal={Psychopharmacology},
  year={1997},
  volume={131},
  pages={71-78}
}
Abstract  Methylphenidate (Ritalin) is the most commonly prescribed psychoactive medication for children in the US where it is used for the treatment of attention deficit hyperactivity disorder. Methylphenidate is marketed as a racemic mixture of the d-threo and l-threo enantiomers. It is believed that the d enantiomer is responsible for the therapeutic effect of methylphenidate. In this study we labeled the individual enantiomers with carbon-11 and compared their binding and pharmacokinetics… Expand
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