Chiral calcium catalysts with neutral coordinative ligands: enantioselective 1,4-addition reactions of 1,3-dicarbonyl compounds to nitroalkenes.

@article{Tsubogo2009ChiralCC,
  title={Chiral calcium catalysts with neutral coordinative ligands: enantioselective 1,4-addition reactions of 1,3-dicarbonyl compounds to nitroalkenes.},
  author={Tetsu Tsubogo and Yasuhiro Yamashita and Shū Kobayashi},
  journal={Angewandte Chemie},
  year={2009},
  volume={48 48},
  pages={9117-20}
}
Alkaline earth metals are among the most promising metallic species in organic synthesis owing to their abundance and low toxicity. Since the first report of their use as a chiral catalyst in 1998, there have been several reports of their use in asymmetric catalysis; however, their reactivity and selectivity are lower in most cases compared with those of other chiral metal-catalyzed reactions. Recently, we developed the 1,4-addition and the [3+2]-cycloaddition reactions of glycine Schiff bases… CONTINUE READING