Chiral Separation of Ketoprofen Enantiomers by Preparative and Simulated Moving Bed Chromatography

  title={Chiral Separation of Ketoprofen Enantiomers by Preparative and Simulated Moving Bed Chromatography},
  author={Ant{\'o}nio E Ribeiro and P. Gomes and L. Pais and A. Rodrigues},
  journal={Separation Science and Technology},
  pages={1726 - 1739}
  • António E Ribeiro, P. Gomes, +1 author A. Rodrigues
  • Published 2011
  • Chemistry
  • Separation Science and Technology
  • The pharmaceutical industry is now directed to the market of more safety and efficient drugs, based on single enantiomers. Ketoprofen, still used as a racemic pharmaceutical drug, belongs to the profens class, one of the most representative of the non-steroidal anti-inflammatory drugs. This work presents the chiral separation of ketoprofen enantiomers by simulated moving bed technology, using a laboratory scale unit (the FlexSMB-LSRE®) with six columns, packed with the Chiralpak AD® stationary… CONTINUE READING
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