• DOI:10.1080/01496395.2011.582070
Corpus ID: 98652570

Chiral Separation of Ketoprofen Enantiomers by Preparative and Simulated Moving Bed Chromatography

@article{Ribeiro2011ChiralSO,
  title={Chiral Separation of Ketoprofen Enantiomers by Preparative and Simulated Moving Bed Chromatography},
  author={Ant{\'o}nio E Ribeiro and P. Gomes and L. Pais and A. Rodrigues},
  journal={Separation Science and Technology},
  year={2011},
  volume={46},
  pages={1726 - 1739}
}

António E Ribeiro, P. Gomes, +1 author A. Rodrigues

Published 2011

Chemistry

Separation Science and Technology

The pharmaceutical industry is now directed to the market of more safety and efficient drugs, based on single enantiomers. Ketoprofen, still used as a racemic pharmaceutical drug, belongs to the profens class, one of the most representative of the non-steroidal anti-inflammatory drugs. This work presents the chiral separation of ketoprofen enantiomers by simulated moving bed technology, using a laboratory scale unit (the FlexSMB-LSRE®) with six columns, packed with the Chiralpak AD® stationary… CONTINUE READING

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