Chiral Separation and Enantiomeric Purity Determination of Pazufloxacin Mesilate by HPLC Using Chiral Mobile Phase Additives

@inproceedings{Zhang2004ChiralSA,
  title={Chiral Separation and Enantiomeric Purity Determination of Pazufloxacin Mesilate by HPLC Using Chiral Mobile Phase Additives},
  author={Zhefeng Zhang and Gengliang Yang and Dexian Wang and Guijian Liang and Yi Chen},
  year={2004}
}
Abstract In this work, a chiral separation method based on an ODS column and chiral mobile phase additives (CMPA) for a new fluoroquinolones drug pazufloxacin mesilate [(−)‐(S)‐10‐(1‐amino‐cyclopropyl)‐9‐fluoro‐3‐methyl‐7‐oxo‐2,3‐dihydro‐7H‐pyrido(1,2,3‐de)‐1,4‐benzoxazine‐6‐carboxylic acid mesilate] and its R‐(+)‐enantiomer was developed. The chiral separation was performed on a Shimadzu CLC‐ODS column (150 × 6.3 mm, 10 µm), methanol–phenylalanine solution (containing 8 mmol L−1 L… CONTINUE READING