Chiral Rhodium(III) Complex-Catalyzed Cascade Michael-Alkylation Reactions: Enantioselective Synthesis of Cyclopropanes.


Chiral Rh(III) complex catalyzed highly efficient enantioselective cyclopropanation of α,β-unsaturated 2-acyl imidazoles or pyridine with 2-bromomalonate is developed to generate corresponding multisubstituted cyclopropanes in 70-99% yields with 93→99% enantioselectivity. The proficiency of the process is also demonstrated in gram scale reaction maintaining… (More)
DOI: 10.1021/acs.joc.6b02583


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