Chiral N-Acetyl Selone-Promoted Aldol Reactions

  title={Chiral N-Acetyl Selone-Promoted Aldol Reactions},
  author={Louis A. “Pete” Silks and David B. Kimball and Duane Michael Hatch and Morgane Ollivault-Shiflett and Ryszard Michalczyk and Eddie W. Moody},
  journal={Synthetic Communications},
  pages={641 - 653}
Abstract The chiral oxazolidineselone functionality was found to be an excellent partner in the stereospecific acetate aldol reaction with aldehydes via the titanium enolates. Good stereocontrol was obtained as determined by NMR spectroscopy. The oxazolidineselone also provided a straightforward way to establish the stereopurity of the coupling reaction through 77Se NMR spectroscopy. 

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