Chiral Microenvironments in Self-Assembled Capsules


A nonracemic compound is synthesized and shown to assemble reversibly through hydrogen bonding to form a cyclic tetramer. The chiral arrangement of atoms in the individual pieces becomes amplified through self-assembly to yield multiple functional groups asymmetrically arranged within the cavity. The tetrameric capsule shows a special affinity for ketones and is able to discriminate between their enantiomers in solution.

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@inproceedings{Nuckolls1999ChiralMI, title={Chiral Microenvironments in Self-Assembled Capsules}, author={Colin Nuckolls}, year={1999} }