Chiral 1,4-benzodiazepin-2-ones: relationship between stereochemistry and pharmacological activity.

@article{Salvadori1989Chiral1R,
  title={Chiral 1,4-benzodiazepin-2-ones: relationship between stereochemistry and pharmacological activity.},
  author={Piero Salvadori and Carlo Bertucci and E Domenici and Gino Giannaccini},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={1989},
  volume={7 12},
  pages={1735-42}
}
Pure enantiomers of 3-substituted-1,4-benzodiazepin-2-ones, obtained by HPLC resolution on chiral stationary phases, show significant differences in their pharmacological activity. The occurrence of biotransformation during the pharmacological test is monitored using a new chromatographic method. The reliability of the pharmacological activity data is discussed.