Chiral, fully extended helical peptides

@article{Crisma2011ChiralFE,
  title={Chiral, fully extended helical peptides},
  author={Marco Crisma and Alessandro Moretto and Cristina Peggion and Lavinia Panella and Bernard Kaptein and Quirinus B. Broxterman and Fernando Formaggio and C. Toniolo},
  journal={Amino Acids},
  year={2011},
  volume={41},
  pages={629-641}
}
The synthesis of the N-protected (blocked) homo-peptide esters from the chiral Cα-ethyl, Cα-n-pentylglycine was performed in solution to the hexapeptide level. The conformational propensity exhibited by these oligomers in chloroform solution and in the crystal state was assessed by use of FTIR absorption, NMR, and X-ray diffraction. The results indicated that fully extended helical structures (2.05-helices) are overwhelmingly adopted irrespective of the peptide main-chain length. This… CONTINUE READING

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