Chiral, fully extended helical peptides

  title={Chiral, fully extended helical peptides},
  author={Marco Crisma and Alessandro Moretto and Cristina Peggion and Lavinia Panella and Bernard Kaptein and Quirinus B. Broxterman and Fernando Formaggio and C. Toniolo},
  journal={Amino Acids},
The synthesis of the N-protected (blocked) homo-peptide esters from the chiral Cα-ethyl, Cα-n-pentylglycine was performed in solution to the hexapeptide level. The conformational propensity exhibited by these oligomers in chloroform solution and in the crystal state was assessed by use of FTIR absorption, NMR, and X-ray diffraction. The results indicated that fully extended helical structures (2.05-helices) are overwhelmingly adopted irrespective of the peptide main-chain length. This… CONTINUE READING


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The first fully planar C5 conformation of homooligopeptides prepared from a chiral aethylated a,a-disubstituted amino acid: (S)-butylethylglycine (=(2S)-2-amino-2-ethylhexanoic acid)

  • N Imawaka, M Tanaka, H Suemune
  • Helv Chim Acta
  • 2000
Highly Influential
12 Excerpts

Structural versatility of peptides from C a , adialkylated glycines . II . An IR absorption and 1 H NMR study homooligopeptides from C a , adiethylglycine

  • C Toniolo, M Crisma, F Formaggio, C Peggion
  • Biopolymers
  • 1988
Highly Influential
12 Excerpts

Structures of polypeptides from aamino acids disubstituted at the a-carbon

  • C Toniolo, E Benedetti
  • Macromolecules
  • 1991
Highly Influential
8 Excerpts

The fully extended polypeptide conformation

  • C Toniolo, E Benedetti
  • Indian Academy of Sciences,
  • 1991
Highly Influential
8 Excerpts

C-Symmetrically disubstituted glycines: useful building blocks in the design of conformationally restricted peptides

  • C Toniolo
  • 1993
Highly Influential
4 Excerpts

Enantioseparation of amino compounds by derivatization with ophthaldialdehyde and D-3-mercapto-2-methylpropionic acid

  • ALL Duchateau, H Knuts, JMM Boesten, JJ Guns
  • J Chromatogr
  • 1992
Highly Influential
2 Excerpts

Étude expérimentale de la conformation de molécules dipeptidiques Comparaison avec les prévisions théoriques

  • MT Cung, M Marraud, J Néel
  • Ann Chim (Paris)
  • 1972
Highly Influential
4 Excerpts

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