Chip-based detection of hepatitis C virus using RNA aptamers that specifically bind to HCV core antigen.

@article{Lee2007ChipbasedDO,
  title={Chip-based detection of hepatitis C virus using RNA aptamers that specifically bind to HCV core antigen.},
  author={Seram Lee and Y S Kim and Minjung Jo and Moonsoo Jin and Dong-ki Lee and Soyoun Kim},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={358 1},
  pages={47-52}
}
The development of reagents with high affinity and specificity to the antigens of hepatitis C virus (HCV) is important for the early stage diagnosis of its infection. Aptamers are short, single-stranded oligonucleotides with the ability to specifically recognize target molecules with high affinity. Herein, we report the selection of RNA aptamers that bind to the core antigen of HCV. High affinity aptamers were isolated from a 10(15) random library of 60 mer RNAs using the SELEX procedure… CONTINUE READING

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Hepatitis

  • U. Weiss
  • Nature 436
  • 2005
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