Chinifur, a selective inhibitor and "subversive substrate" for Trypanosoma congolense trypanothione reductase.

@article{nas1994ChinifurAS,
  title={Chinifur, a selective inhibitor and "subversive substrate" for Trypanosoma congolense trypanothione reductase.},
  author={Narimantas K. {\vC}ėnas and Daiva Bironaite and E Dickancait{\'e} and Žilvinas Anusevi{\vc}ius and Jonas {\vS}arlauskas and John S Blanchard},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={204 1},
  pages={224-9}
}
Nitrofurans with aromatic and heterocyclic substituents inhibit Trypanosoma congolense trypanothione reductase (TR) and yeast glutathione reductase (GR), acting as uncompetitive inhibitors vs. NADPH and noncompetitive or uncompetitive inhibitors vs. disulfide substrate. Many of these compounds inhibited trypanothione reductase more efficiently than glutathione reductase. Chinifur (2-[5'-nitro(furo-2'-yl)-ethene-1-yl]-4(N,N-diethylamino)-1-methyl-but-1 -yl - aminocarbonyl-4-quinoline) was the… CONTINUE READING