Chinese scientists genetically modify human embryos

  title={Chinese scientists genetically modify human embryos},
  author={David Cyranoski and Sara Reardon},
Rumours of germline modification prove true — and look set to reignite an ethical debate. 
CRISPR/Cas9 and Germline Modification: New Difficulties in Obtaining Informed Consent
This research presents a new approach to selective breeding called “superficial selection”, which aims to find the most efficient way to breed animals with high levels of genetic diversity. Expand
Human Genome Editing and Ethical Considerations
It needs to be seen as to what transformation human gene editing brings to humankind in the times to come. Expand
Crossing the Germline Barrier: The Three Genome Baby
The origins of the somatic cell and germline moral distinction are discussed, new initiatives to undertake genetic modification of gametes or embryos are explored and new efforts to prevent the transfer of certain deleterious genes are explored. Expand
The ethics of genome editing in the clinic: A dose of realism for healthcare leaders
The ethical and societal issues raised by genome editing technologies are discussed, including their use in preclinical research, their potential to address mutations in somatic cells, and the potential to make germ line alterations that may be passed to subsequent generations. Expand
CRISPR Update: Considerations for a Rapidly Evolving and Transformative Technology
Earlier this year, only a few months after the Chinese stunned the world by announcing that they had edited genes in human embryos,[1] the British Human Fertilisation & Embryology Authority (HFEA)Expand
Germline Editing: Editors Cautionary.
The researchers need to be doubly cautious and some stringent regulations should be framed regarding the various aspects of germ line gene modifications and any potential conflict with nature for future outcome. Expand
On the Future Advances in Engineering and In-Vitro Culture of Human Embryos
The unanimously unmentioned future "human embryo-based (embryogenic) transplantation methods" are first claimed here as a potential and very powerful biomedical strategy that could now become enabled in the future due to these recent new protocols that could cause an unseen political and societal dilemma regarding their adequate, international, and humane regulation. Expand
Ethics and germline gene editing
Although these experiments were performed in nonviable, triploid embryos that were neither intended nor suitable for clinical use, the work nonetheless demonstrates how the prospect of manipulating the human germline elicits hopes and fears and triggers moral debates. Expand
Biotechnological challenges: The scope of genome editing
While the genome editing of species, including animals, plants and bacteria has become a commonly used method, the application of CRISPR-Cas9 in human embryos has led to debates and interdisciplinary discussions. Expand
Opinion on the Legal Framework Concerning Interventions in Human Germline Genes in Belgium
  • H. Nys
  • Biology
  • Veröffentlichungen des Instituts für Deutsches, Europäisches und Internationales Medizinrecht, Gesundheitsrecht und Bioethik der Universitäten Heidelberg und Mannheim
  • 2019
The announcement in April 2015 of genome editing of non-viable human embryos using CRISPR-Cas9 demonstrated that human germline modification has moved out of the realm of the theoretical. Expand


Don’t edit the human germ line
Concerns are concerned that a public outcry about such an ethical breach could hinder a promising area of therapeutic development, namely making genetic changes that cannot be inherited, and at this early stage, scientists should agree not to modify the DNA of human reproductive cells. Expand
A prudent path forward for genomic engineering and germline gene modification
The meeting identified immediate steps to take toward ensuring that the application of genome engineering technology is performed safely and ethically, and identified those areas where action is essential to prepare for future developments. Expand
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
It is found that CRISPR/Cas9 could effectively cleave the endogenous β-globin gene (HBB), however, the efficiency of homologous recombination directed repair (HDR) of HBB was low and the edited embryos were mosaic. Expand