Chinese scientists genetically modify human embryos

@article{Cyranoski2015ChineseSG,
  title={Chinese scientists genetically modify human embryos},
  author={David Cyranoski and Sara Reardon},
  journal={Nature},
  year={2015}
}
Rumours of germline modification prove true — and look set to reignite an ethical debate. 
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Although these experiments were performed in nonviable, triploid embryos that were neither intended nor suitable for clinical use, the work nonetheless demonstrates how the prospect of manipulating the human germline elicits hopes and fears and triggers moral debates.
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Opinion on the Legal Framework Concerning Interventions in Human Germline Genes in Belgium
  • H. Nys
  • Biology
    Veröffentlichungen des Instituts für Deutsches, Europäisches und Internationales Medizinrecht, Gesundheitsrecht und Bioethik der Universitäten Heidelberg und Mannheim
  • 2019
TLDR
The announcement in April 2015 of genome editing of non-viable human embryos using CRISPR-Cas9 demonstrated that human germline modification has moved out of the realm of the theoretical.
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References

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Don’t edit the human germ line
TLDR
Concerns are concerned that a public outcry about such an ethical breach could hinder a promising area of therapeutic development, namely making genetic changes that cannot be inherited, and at this early stage, scientists should agree not to modify the DNA of human reproductive cells.
A prudent path forward for genomic engineering and germline gene modification
TLDR
The meeting identified immediate steps to take toward ensuring that the application of genome engineering technology is performed safely and ethically, and identified those areas where action is essential to prepare for future developments.
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
TLDR
It is found that CRISPR/Cas9 could effectively cleave the endogenous β-globin gene (HBB), however, the efficiency of homologous recombination directed repair (HDR) of HBB was low and the edited embryos were mosaic.