Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.

@article{Sehested1998ChineseHO,
  title={Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.},
  author={Maxwell Sehested and Irene Wessel and Lars Hornb{\ae}k Jensen and Bjoern Holm and Roberto Stefan Oliveri and Susan Kenwrick and Andrew Malcolm Creighton and John L Nitiss and Peter Bj{\o}dstrup Jensen},
  journal={Cancer research},
  year={1998},
  volume={58 7},
  pages={
          1460-8
        }
}
Anticancer drugs targeted to the nuclear enzyme DNA topoisomerase II are classified as poisons that lead to DNA breaks or catalytic inhibitors that appear to completely block enzyme activity. To examine the effects of the bisdioxopiperazine class of catalytic inhibitors to topoisomerase II, we investigated a Chinese hamster ovary (CHO) subline selected for resistance to ICRF-159 (CHO/159-1). Topoisomerase IIalpha content in CHO/159-1 cells was reduced by 40-50%, compared to wild-type CHO cells… CONTINUE READING

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SHOWING 1-10 OF 37 REFERENCES

Studies on the mechanism of induced resistance to antitumor agent ICRF-159 in mammalian cell lines (Thesis)

S J.Kenwrick.
  • 1984
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane ( ICRF - 187 ) catalytic inhibitor of topoisomerase II

B. B. Hasinoff, I. Kuschak.T., +3 authors J. C. Yalowich
  • Biochem . Pharmacol . .
  • 1997

Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase

B HasinoffB., T I.Kuschak., +4 authors C YalowichJ.
  • II. Biochem. Pharmacol.
  • 1997
VIEW 2 EXCERPTS

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