Chinese hamster ovary cells resistant to okadaic acid express a multidrug resistant phenotype.

@article{Tohda1994ChineseHO,
  title={Chinese hamster ovary cells resistant to okadaic acid express a multidrug resistant phenotype.},
  author={Hiroko Tohda and Akira Yasui and Takeshi Yasumoto and Michie Nakayasu and Hiroshi Shima and Masaya Nagao and Takashi Sugimura},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={203 2},
  pages={1210-6}
}
Two Chinese hamster ovary cell clones resistant to okadaic acid (OA) were isolated. The OA-resistance was associated with resistance to colchicine, Vinca alkaloids and inhibitors of DNA topoisomerase (topo) II. Drug accumulation assays showed that the intracellular levels of OA, vinblastine and vincristine, but not the topo II inhibitor etoposide, were… CONTINUE READING