Chinese hamster ovary cell growth and interferon production kinetics in stirred batch culture

@article{Hayter1991ChineseHO,
  title={Chinese hamster ovary cell growth and interferon production kinetics in stirred batch culture},
  author={Paul M. Hayter and E. M. A. Curling and Anthony J. Baines and Nigel Jenkins and Isabelle Salmon and Philip G. Strange and Alan T Bull},
  journal={Applied Microbiology and Biotechnology},
  year={1991},
  volume={34},
  pages={559-564}
}
Recombinant human interferon-λ production by Chinese hamster ovary cells was restricted to the growth phase of batch cultures in serum-free medium. The specific interferon production rate was highest during the initial period of exponential growth but declined subsequently in parallel with specific growth rate. This decline in specific growth rate and interferon productivity was associated with a decline in specific metabolic activity as determined by the rate of glucose uptake and the rates of… CONTINUE READING
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