Chinese hamster fibroblasts overexpressing CuZn-superoxide dismutase undergo a global reduction in antioxidants and an increasing sensitivity of DNA to oxidative damage.

@article{Teixeira1996ChineseHF,
  title={Chinese hamster fibroblasts overexpressing CuZn-superoxide dismutase undergo a global reduction in antioxidants and an increasing sensitivity of DNA to oxidative damage.},
  author={Herbert Teixeira and Rogerio Meneghini},
  journal={The Biochemical journal},
  year={1996},
  volume={315 ( Pt 3)},
  pages={
          821-5
        }
}
Transfection of a CuZn-superoxide dismutase (SOD) expression vector into V79 Chinese hamster cells produced clones in which CuZn-SOD activities were 2.2-3.5-fold higher than in the parental cells. An overall moderate reduction of glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase activities and of both GSSG and total glutathione levels was found. In one particular clone the catalase activity was also reduced. The pro-oxidant status established by the lower level… CONTINUE READING

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