Chimpanzee-human monoclonal antibodies for treatment of chronic poliovirus excretors and emergency postexposure prophylaxis.

@article{Chen2011ChimpanzeehumanMA,
  title={Chimpanzee-human monoclonal antibodies for treatment of chronic poliovirus excretors and emergency postexposure prophylaxis.},
  author={Zhaochun Chen and Konstantin P Chumakov and Eugenia M. Dragunsky and Diana V. Kouiavskaia and Michelle Makiya and Alexander A. Neverov and Gennady V Rezapkin and Andrew Sebrell and Robert J. Purcell},
  journal={Journal of virology},
  year={2011},
  volume={85 9},
  pages={
          4354-62
        }
}
Six poliovirus-neutralizing Fabs were recovered from a combinatorial Fab phage display library constructed from bone marrow-derived lymphocytes of immunized chimpanzees. The chimeric chimpanzee-human full-length IgGs (hereinafter called monoclonal antibodies [MAbs]) were generated by combining a chimpanzee IgG light chain and a variable domain of heavy chain with a human constant Fc region. The six MAbs neutralized vaccine strains and virulent strains of poliovirus. Five MAbs were serotype… CONTINUE READING

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