Chimpanzee adenovirus CV-68 adapted as a gene delivery vector interacts with the coxsackievirus and adenovirus receptor.

@article{Cohen2002ChimpanzeeAC,
  title={Chimpanzee adenovirus CV-68 adapted as a gene delivery vector interacts with the coxsackievirus and adenovirus receptor.},
  author={Christopher J Cohen and Z. Q. Xiang and Guang-ping Gao and Hildegund C J Ertl and James Michael Wilson and Jeffrey M. Bergelson},
  journal={The Journal of general virology},
  year={2002},
  volume={83 Pt 1},
  pages={151-5}
}
A replication-defective form of chimpanzee adenovirus type 68 (C68) has been developed to circumvent problems posed by widespread preexisting immunity to common human adenovirus vectors. To investigate the determinants of C68 tropism, its interaction with the coxsackievirus and adenovirus receptor (CAR) was studied. Although CHO cells were resistant to transduction by C68 as well as by adenovirus type 5 (Ad5), CHO cells expressing either human or murine CAR were transduced readily. C68… CONTINUE READING

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