Chimpanzee Down syndrome: a case study of trisomy 22 in a captive chimpanzee

@article{Hirata2017ChimpanzeeDS,
  title={Chimpanzee Down syndrome: a case study of trisomy 22 in a captive chimpanzee},
  author={Satoshi Hirata and Hirohisa Hirai and Etsuko Nogami and Naruki Morimura and Toshifumi Udono},
  journal={Primates},
  year={2017},
  volume={58},
  pages={267-273}
}
We report a case of chimpanzee trisomy 22 in a captive-born female. Because chromosome 22 in great apes is homologous to human chromosome 21, the present case is analogous to human trisomy 21, also called Down syndrome. The chimpanzee in the present case experienced retarded growth; infantile cataract and vision problems, including nystagmus, strabismus, and keratoconus; congenital atrial septal defect; and hypodontia. All of these symptoms are common in human Down syndrome. This case was the… 
View on Springer
repository.kulib.kyoto-u.ac.jp
15 Citations

15 Citations

Citation Type

Citation Type

Genetic diagnosis of trisomy 21 in chimpanzees (Pan troglodytes)
TLDR
The first application of sequencing data as a diagnostic tool to compare chromosomal dosage imbalances in chimpanzees is presented, and evidence suggests that prevalence of T21 in chimpanzees could be lower than in humans.
Identification of Chromosome 17 Trisomy in a Cynomolgus Monkey (Macaca fascicularis) by Multicolor FISH Techniques
TLDR
A female cynomolgus monkey with facial features characteristic of Down syndrome showed abnormal behavior, unwariness toward humans, and poor concentration, and this individual's case could help to reveal the pathological and genetic mechanisms of Patau syndrome.
Chimpanzee Kanako
Kanako was a female chimpanzee who was born on 2 June 1992 at a facility in Kumamoto, Japan, which was then owned by a pharmaceutical company. She passed away peacefully in the morning of 12 February…
Genetics and genomics of Down syndrome
TLDR
It is illustrated how recent genomic science may be useful in the elucidation of the genotype-phenotype relationship in DS.
All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics.
Human chromosome 21 (Hsa21) contains more than 500 genes, making trisomy 21 one of the most complex genetic perturbations compatible with life. The ultimate goal of Down syndrome (DS) research is to…
Disfunciones en primates no humanos. La discapacidad desde una perspectiva evolutiva
A systematic and updated review of the literature on disability in non-human primates is presented. The information obtained shows that in several primate species, individuals with malformations and…
A preliminary investigation on the evaluation of psychopathologies in a group of ex-pet and ex-performer chimpanzees (Pan troglodytes): A rating approach based on the Diagnostic and Statistical Manual of Mental Disorders (DSM)
Abstract The diagnosis of psychopathologies in nonhuman primates has received increasing interest in the last decade. However, only a limited number of categories of pathology have been diagnosed in…
A review of research in primate sanctuaries
TLDR
The range and form of research that has been conducted at accredited sanctuaries around the world are examined, including large, naturalistic physical and social environments which may result in more relevant models of primates' free-ranging wild counterparts than other captive settings.
WISH cages: constructing multiple habitats for captive chimpanzees
TLDR
Environmental enrichment for captive chimpanzees in Japan in a historical context is introduced and the most recent endeavor of constructing huge cages and connecting multiple habitats is described, which involve what the authors call “WISH” cages, which have been constructed in PRI and KS.
Clinical presentation, treatment, and genetic and histopathological analysis of juvenile cataracts and secondary glaucoma in a rhesus macaque (Macaca mulatta).
This report describes the clinical and histological findings, genetic study, and treatment in a 1.3-year-old rhesus macaque with bilateral cataracts and unilateral secondary glaucoma. Intravitreal…
...
1
2
...

References

SHOWING 1-10 OF 45 REFERENCES
Conservation of the Down syndrome critical region in humans and great apes.
TLDR
Results support the notion that the Down syndrome critical region of human chromosome 21 band q22.3 is conserved in great apes, which has displayed mongolism in a chimpanzee when present in triplicate conditions.
Autosomal Trisomy in a Chimpanzee: Resemblance to Down's Syndrome
An infant chimpanzee (Pan troglodytes) with clinical, behavioral, and cytogenetic features similar to those in Down's syndrome is described. The infant shows retarded growth rate, congenital…
Down syndrome genetics: unravelling a multifactorial disorder.
TLDR
Recent advances on a number of fronts, including chromosome studies, gene identification and mouse modelling, are giving us the tools to dissect this multifactorial gene dosage disorder.
An observation of a severely disabled infant chimpanzee in the wild and her interactions with her mother
TLDR
The mother's compensatory care for her infant’s disabilities and allomothering of the infant by its sister might have helped it to survive for 23 months in the wild.
Origin of Human Chromosome 21 and its Consequences: a 50-million-year-old Story
TLDR
The ancestral HSA21 was formed after the divergence between platyrrhines and catarrhines and before the emergence of Cercopithecidae, which exposed the human and Pongidae ancestry to trisomy 21 for a period of 30-50 million years.
A case of trisomy 22 in Pongo pygmaeus.
A behaviorally and clinically abnormal female orangutan was analyzed cytologically using general banding techniques and by an alkaline silver method for staining nucleolus organizer regions. The…
Euthanasia is not an option: 10 years’ care of a chimpanzee with acute tetraparesis
TLDR
Following physical therapy and the use of a novel computer-assisted rehabilitation program, he can now walk unaided, and this specially designed innovative system to facilitate walking involves a touch-screen cognitive task.
The first chimpanzee sanctuary in Japan: an attempt to care for the “surplus” of biomedical research
TLDR
Several aspects of the human–captive chimpanzee bond and the effort to create the first chimpanzee sanctuary in Japan are examined and ethical responsibility for captive chimpanzees that have been used in biomedical research is discussed.
Chromosomal evolution in Primates: Tentative phylogeny from Microcebus murinus (Prosimian) to man
TLDR
The karyotypes of more than 60 species of Primates are studied and compared, with the use of almost all existing banding techniques, and a fairly precise genealogy of many Primates is proposed, giving the positions of the Catarrhines, the Platyrrhines, and the Prosimians is proposed.
Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.
  • A. Jauch, J. Wienberg, +4 authors T. Cremer
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1992
TLDR
This work used chromosomal in situ suppression hybridization of all human chromosome-specific DNA libraries to "paint" the chromosomes of primates and establish homologies between the human, great ape, and gibbon karyotypes.
...
1
2
3
4
5
...