Chimpanzee Down syndrome: a case study of trisomy 22 in a captive chimpanzee
@article{Hirata2017ChimpanzeeDS, title={Chimpanzee Down syndrome: a case study of trisomy 22 in a captive chimpanzee}, author={S. Hirata and H. Hirai and E. Nogami and N. Morimura and T. Udono}, journal={Primates}, year={2017}, volume={58}, pages={267-273} }
We report a case of chimpanzee trisomy 22 in a captive-born female. Because chromosome 22 in great apes is homologous to human chromosome 21, the present case is analogous to human trisomy 21, also called Down syndrome. The chimpanzee in the present case experienced retarded growth; infantile cataract and vision problems, including nystagmus, strabismus, and keratoconus; congenital atrial septal defect; and hypodontia. All of these symptoms are common in human Down syndrome. This case was the… CONTINUE READING
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References
SHOWING 1-10 OF 45 REFERENCES
Conservation of the Down syndrome critical region in humans and great apes.
- Biology, Medicine
- Gene
- 1995
- 18
Autosomal Trisomy in a Chimpanzee: Resemblance to Down's Syndrome
- Biology, Medicine
- Science
- 1969
- 74
- Highly Influential
Down syndrome genetics: unravelling a multifactorial disorder.
- Biology, Medicine
- Human molecular genetics
- 1996
- 76
- Highly Influential
- PDF
An observation of a severely disabled infant chimpanzee in the wild and her interactions with her mother
- Psychology, Medicine
- Primates
- 2015
- 23
- PDF
Origin of Human Chromosome 21 and its Consequences: a 50-million-year-old Story
- Biology, Medicine
- Chromosome Research
- 2004
- 20
Euthanasia is not an option: 10 years’ care of a chimpanzee with acute tetraparesis
- Medicine
- Primates
- 2016
- 3
- PDF
The first chimpanzee sanctuary in Japan: an attempt to care for the “surplus” of biomedical research
- Political Science, Medicine
- American journal of primatology
- 2011
- 41
- PDF
Chromosomal evolution in Primates: Tentative phylogeny from Microcebus murinus (Prosimian) to man
- Biology, Medicine
- Human Genetics
- 2004
- 195
- Highly Influential
Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1992
- 281
- PDF