Chimpanzee Down syndrome: a case study of trisomy 22 in a captive chimpanzee

  title={Chimpanzee Down syndrome: a case study of trisomy 22 in a captive chimpanzee},
  author={Satoshi Hirata and Hirohisa Hirai and Etsuko Nogami and Naruki Morimura and Toshifumi Udono},
We report a case of chimpanzee trisomy 22 in a captive-born female. Because chromosome 22 in great apes is homologous to human chromosome 21, the present case is analogous to human trisomy 21, also called Down syndrome. The chimpanzee in the present case experienced retarded growth; infantile cataract and vision problems, including nystagmus, strabismus, and keratoconus; congenital atrial septal defect; and hypodontia. All of these symptoms are common in human Down syndrome. This case was the… 
15 Citations
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Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.
  • A. Jauch, J. Wienberg, +4 authors T. Cremer
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1992
This work used chromosomal in situ suppression hybridization of all human chromosome-specific DNA libraries to "paint" the chromosomes of primates and establish homologies between the human, great ape, and gibbon karyotypes.