Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation.

@article{Leventhal2012ChimerismAT,
  title={Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation.},
  author={Joseph R. Leventhal and Michael M I Abecassis and Joshua Miller and Lorenzo G Gallon and Kadiyala Ravindra and David J. Tollerud and Bradley M King and Mary Jane Elliott and Geoffrey P. Herzig and Roger H. Herzig and Suzanne T. Ildstad},
  journal={Science translational medicine},
  year={2012},
  volume={4 124},
  pages={124ra28}
}
The toxicity of chronic immunosuppressive agents required for organ transplant maintenance has prompted investigators to pursue approaches to induce immune tolerance. We developed an approach using a bioengineered mobilized cellular product enriched for hematopoietic stem cells (HSCs) and tolerogenic graft facilitating cells (FCs) combined with nonmyeloablative conditioning; this approach resulted in engraftment, durable chimerism, and tolerance induction in recipients with highly mismatched… CONTINUE READING
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CD 8 a + plasmacytoid precursor DCs induce antigen - specific regulatory T cells that enhance HSC engraftment in vivo

  • L. D. Bozulic Huang, T. Miller, H. Xu, L. R. Hussain, S. T. Ildstad
  • Blood
  • 2011

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