Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in mice.

@article{Pletnev1993ChimericTE,
  title={Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in mice.},
  author={Alexander G. Pletnev and Michael Bray and C J Lai},
  journal={Journal of virology},
  year={1993},
  volume={67 8},
  pages={4956-63}
}
Two new chimeric flaviviruses were constructed from full-length cDNAs that contained tick-borne encephalitis virus (TBEV) CME or ME structural protein genes and the remaining genes derived from dengue type 4 virus (DEN4). Studies involving mice inoculated intracerebrally with the ME chimeric virus indicated that it retained the neurovirulence of its TBEV parent from which its pre-M and E genes were derived. However, unlike parental TBEV, the chimeric virus did not produce encephalitis when mice… CONTINUE READING

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