Chimeric strategies for the rational design of bioactive analogs of small peptide hormones.

@article{Howl1997ChimericSF,
  title={Chimeric strategies for the rational design of bioactive analogs of small peptide hormones.},
  author={John Howl and U¨lo Langel and Stuart R. Hawtin and Andres Valkna and Nga Yarwood and K{\"u}lliki Saar and Mark Adrian Wheatley},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1997},
  volume={11 7},
  pages={
          582-90
        }
}
The aim of this study was to evaluate a variety of synthetic strategies pertinent to the development of chimeric analogs of the structurally divergent nonapeptide hormones arginine vasopressin (AVP) and bradykinin (BK). Single-chain peptides combining AVP and BK directly, AVP(1-9)-BK(1-9) or via a flexible aminohexanoic acid (epsilonAhx) linker, AVP(1-9)-epsilonAhx-BK(1-9), bind with relatively high affinity to the bovine kidney medulla B2a bradykinin receptor (B2a BKR). Significantly, amino… CONTINUE READING