Chimeric recombinant hepatitis E virus-like particles as an oral vaccine vehicle presenting foreign epitopes.

@article{Niikura2002ChimericRH,
  title={Chimeric recombinant hepatitis E virus-like particles as an oral vaccine vehicle presenting foreign epitopes.},
  author={Masahiro Niikura and Shiki Takamura and Gisen Kim and Satoru Kawai and Masayuki Saijo and S. R. K. Morikawa and Ichiro Kurane and Tian-cheng Li and Naokazu Takeda and Yasuhiro Yasutomi},
  journal={Virology},
  year={2002},
  volume={293 2},
  pages={273-80}
}
Many viral and bacterial pathogens establish infections through mucosal surfaces in their initial stage. However, only a few nonreplicating molecules successfully induce strong mucosal immune reaction without the addition of adjuvants by oral administration. To overcome this difficulty, we investigated whether hepatitis E virus-like particles (HEV-VLPs) could be utilized as a carrier molecule for foreign antigenic epitopes and to stimulate mucosal immunity without the need for adjuvants. To… CONTINUE READING

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