Chimeric influenza A viruses with a functional influenza B virus neuraminidase or hemagglutinin.

@article{Flandorfer2003ChimericIA,
  title={Chimeric influenza A viruses with a functional influenza B virus neuraminidase or hemagglutinin.},
  author={Astrid Flandorfer and Adolfo Garc{\'i}a-Sastre and Christopher F Basler and P. Palese},
  journal={Journal of virology},
  year={2003},
  volume={77 17},
  pages={9116-23}
}
Reassortment of influenza A and B viruses has never been observed in vivo or in vitro. Using reverse genetics techniques, we generated recombinant influenza A/WSN/33 (WSN) viruses carrying the neuraminidase (NA) of influenza B virus. Chimeric viruses expressing the full-length influenza B/Yamagata/16/88 virus NA grew to titers similar to that of wild-type influenza WSN virus. Recombinant viruses in which the cytoplasmic tail or the cytoplasmic tail and the transmembrane domain of the type B NA… CONTINUE READING
9 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…