Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies

@article{Artlett2000ChimericCO,
  title={Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies},
  author={Carol M. Artlett and Ronald C Ramos and SergAio A Jiminez and Kathleen Patterson and Frederick W. Miller and Lisa G. Rider},
  journal={The Lancet},
  year={2000},
  volume={356},
  pages={2155-2156}
}
Persistent maternally derived peripheral microchimerism is associated with the juvenile idiopathic inflammatory myopathies.
TLDR
Maternal cells can persist in the peripheral blood of their children up to three decades after birth, and are found in a higher proportion in JIIM patients compared with controls, suggesting that maternal cells may be involved in the immunopathogenesis of JI IM.
Microchimerism in children with rheumatic disorders: What does it mean?
  • A. Reed
  • Biology, Medicine
    Current rheumatology reports
  • 2003
TLDR
Persistence of maternal microchimerism, which is increased in the diseased population and thought associated with human leukocyte antigen genes of the offspring and the mother, has been demonstrated for many years after birth in the child and mother.
Maternal microchimerism in muscle biopsies from children with juvenile dermatomyositis
TLDR
Data confirm an increased frequency of maternal cells in JDM, and more detailed characterization of MMc is required, particularly using phenotypic markers, to explain the role of these cells inJDM.
Chimeric cells of maternal origin do not appear to be pathogenic in the juvenile idiopathic inflammatory myopathies or muscular dystrophy
TLDR
Microchimeric cells are not specific to autoimmune disease, and may not be important in muscle inflammation or tissue repair in JIIM.
Presence of chimeric maternally derived keratinocytes in cutaneous inflammatory diseases of children: the example of pityriasis lichenoides.
TLDR
Maternally derived keratinocytes in the skin of male children with inflammatory skin disorders are identified, which may either help repair the damaged skin or home initially in theskin and trigger a host (child) versus graft (mother) disease.
Detection of maternal-fetal microchimerism in the inflammatory lesions of patients with Sjögren's syndrome
TLDR
Maternal-fetal microchimerism was shown for the first time to exist in the salivary glands and lungs of female patients with Sjögren's syndrome in this study, and the presence of non-host cells in the inflammatory lesions but not in the peripheral blood suggests a possible role for maternal- Fetal micro chimerism in the pathogenesis of SS.
Juvenile Dermatomyositis: Immunopathogenesis, Role of Myositis‐Specific Autoantibodies, and Review of Rituximab Use
TLDR
Given the role of humoral immunity and MSA, there has been recent interest in the use of rituximab to treat JDM, and early results are mixed, but it is hoped that a prospective clinical trial will shed light on the issue in the near future.
Juvenile idiopatiske inflammatoriske myopatier
TLDR
The hallmark of JDM is calcinosis, lipodystrophy and vasculitis, findings that differs the juvenile form of dermatomyosits from the adult form.
Myositis in children.
  • A. Reed
  • Medicine, Biology
    Current opinion in rheumatology
  • 2001
TLDR
Continued investigation is needed to further understand these diseases, but great strides are being made in the understanding and ability to care for children with idiopathic inflammatory myositis.
Maternal microchimerism in Hirschsprung's disease.
TLDR
Clustering of chimeric cells in areas of absent ganglia lends support to the proposed role of maternal microchimerism in allo-autoimmune responses.
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