Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly

Abstract

Telomerase is a key participant in the telomere length maintaining system in eukaryotic cells. Telomerase RNA and protein reverse transcriptase subunits are essential for the appearance of active telomerase in vitro. Telomerase is active in many cancer types and is a potential target for anticancer drug development. Here we report a new approach for… (More)
DOI: 10.1093/nar/gku688

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