Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

@article{Porter2015ChimericAR,
  title={Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia},
  author={David L. Porter and Wei-ting Hwang and Noelle V. Frey and Simon F Lacey and Pamela A Shaw and Alison W. Loren and Adam Bagg and Katherine T. Marcucci and Angela Shen and Vanessa E. Gonzalez and David E Ambrose and Stephan A. Grupp and Anne Chew and Zhaohui Zheng and Michael C Milone and Bruce L Levine and Jan Joseph Melenhorst and Carl H June},
  journal={Science Translational Medicine},
  year={2015},
  volume={7},
  pages={303ra139-303ra139}
}
Patients with multiply relapsed or refractory chronic lymphocytic leukemia (CLL) have a poor prognosis. Chimeric antigen receptor (CAR)–modified T cells targeting CD19 have the potential to improve on the low complete response rates with conventional therapies by inducing sustained remissions in patients with refractory B cell malignancies. We previously reported preliminary results on three patients with refractory CLL. We report the mature results from our initial trial using CAR-modified T… CONTINUE READING
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