Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity.

@article{Kobilka1988ChimericA2,
  title={Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity.},
  author={Brian K. Kobilka and Tong Sun Kobilka and Kiefer W. Daniel and John W. Regan and Marc G. Caron and Robert J Lefkowitz},
  journal={Science},
  year={1988},
  volume={240 4857},
  pages={1310-6}
}
The alpha 2 and beta 2 adrenergic receptors, both of which are activated by epinephrine, but which can be differentiated by selective drugs, have opposite effects (inhibitory and stimulatory) on the adenylyl cyclase system. The two receptors are homologous with each other, rhodopsin, and other receptors coupled to guanine nucleotide regulatory proteins and they contain seven hydrophobic domains, which may represent transmembrane spanning segments. The function of specific structural domains of… CONTINUE READING

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