Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicity.

@article{Xu2015ChimericTM,
  title={Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicity.},
  author={Dan Xu and Manhong Wu and Sachiko Nishimura and Toshihiko Nishimura and Sara A. Michie and Ming Zheng and Zicheng Yang and Alexander Yates and Jeffrey S. Day and Kathleen M. Hillgren and Saori Takeda and Yuan H. Guan and Yingying Guo and Gary Peltz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2015},
  volume={352 2},
  pages={
          274-80
        }
}
Due to the substantial interspecies differences in drug metabolism and disposition, drug-induced liver injury (DILI) in humans is often not predicted by studies performed in animal species. For example, a drug (bosentan) used to treat pulmonary artery hypertension caused unexpected cholestatic liver toxicity in humans, which was not predicted by preclinical toxicology studies in multiple animal species. In this study, we demonstrate that NOG mice expressing a thymidine kinase transgene (TK-NOG… CONTINUE READING

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