Chimeric Fusion Proteins Used for Therapy: Indications, Mechanisms, and Safety

  title={Chimeric Fusion Proteins Used for Therapy: Indications, Mechanisms, and Safety},
  author={B. Baldo},
  journal={Drug Safety},
  • B. Baldo
  • Published 2015
  • Medicine
  • Drug Safety
  • Chimeric fusion proteins, produced by genetic engineering, are currently made up of effector peptides, for example, a ligand-binding portion of a cytokine or growth factor, extracellular domains of lymphocyte antigens, or a toxin linked to a suitable fusion partner. This review covers eight fusion proteins that have received regulatory approval for human therapy: etanercept, belatacept, abatacept, alefacept, rilonacept, romiplostim, aflibercept, and denileukin-diftitox. Important requirements… CONTINUE READING
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