Chimeric 5/35 adenovirus-mediated Dickkopf-1 overexpression suppressed tumorigenicity of CD44+ gastric cancer cells via attenuating Wnt signaling

@article{Wang2012Chimeric5A,
  title={Chimeric 5/35 adenovirus-mediated Dickkopf-1 overexpression suppressed tumorigenicity of CD44+ gastric cancer cells via attenuating Wnt signaling},
  author={Bin Wang and Jia Liu and Lei Ma and Hua liang Xiao and Ya Zhou Wang and Yan Li and Zhe Wang and Linli Fan and Chunhui Lan and Min Yang and Lu Hu and Yanlin Wei and Xiu Wu Bian and Dongfeng Chen and Jun Wang},
  journal={Journal of Gastroenterology},
  year={2012},
  volume={48},
  pages={798-808}
}
  • Bin Wang, Jia Liu, +12 authors Jun Wang
  • Published in Journal of Gastroenterology 2012
  • Medicine
  • BackgroundGastric cancer stem cells (CSCs), which require activation of Wnt signaling to maintain their self-renewal and tumorigenicity, are proposed to be critical targets for effective therapy of gastric carcinomas. Gene therapies that are delivered by adenovirus of serotype 5 (Ad5) or chimeric 5/35(Ad5/35) adenovirus have shown promise for treating various cancers. Here we aimed to develop a gene therapy strategy that targeted gastric CSCs (CD44+ cells).MethodsCD44+ cells were isolated by… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 32 REFERENCES

    Recent patterns in gastric cancer: a global overview.

    VIEW 11 EXCERPTS
    HIGHLY INFLUENTIAL

    Wnt signaling, stem cells, and cancer of the gastrointestinal tract.

    VIEW 1 EXCERPT

    Wnt/β-Catenin Signaling and Disease

    VIEW 1 EXCERPT