Chimeras taking shape: potential functions of proteins encoded by chimeric RNA transcripts.

  title={Chimeras taking shape: potential functions of proteins encoded by chimeric RNA transcripts.},
  author={Milana Frenkel-Morgenstern and Vincent Lacroix and Iakes Ezkurdia and Yishai Levin and Alexandra Gabashvili and Jaime Prilusky and {\'A}ngela del Pozo and Michael L. Tress and Rory Johnson and Roderic Guig{\'o} and Alfonso Valencia},
  journal={Genome research},
  volume={22 7},
Chimeric RNAs comprise exons from two or more different genes and have the potential to encode novel proteins that alter cellular phenotypes. To date, numerous putative chimeric transcripts have been identified among the ESTs isolated from several organisms and using high throughput RNA sequencing. The few corresponding protein products that have been characterized mostly result from chromosomal translocations and are associated with cancer. Here, we systematically establish that some of the… CONTINUE READING
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