Chimaerism shown by cytogenetics and DNA polymorphism analysis.

@article{Green1994ChimaerismSB,
  title={Chimaerism shown by cytogenetics and DNA polymorphism analysis.},
  author={Alistair John Green and David E. Barton and Peter Jenks and John V. Pearson and John R. Yates},
  journal={Journal of medical genetics},
  year={1994},
  volume={31 10},
  pages={
          816-7
        }
}
A child with ambiguous genitalia, brought up phenotypically male, had a 46,XX/46,XY karyotype. At laparotomy, he had a left sided ovary and uterus, and a right sided scrotal testis. The 46,XX line made up 50% of cells in the blood and 90% of cells in a skin biopsy. There were no cytogenetic polymorphisms. Analysis of lymphocyte DNA with seven polymorphic DNA markers showed him to be chimaeric, with four, three, and two parental alleles at different loci. He had one paternal and one maternal X… CONTINUE READING

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