Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac.

@article{Yang2007ChimaerinsGT,
  title={Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac.},
  author={Chengfeng Yang and Marcelo G Kazanietz},
  journal={The Biochemical journal},
  year={2007},
  volume={403 1},
  pages={1-12}
}
Chimaerins are the only known RhoGAPs (Rho GTPase-activating proteins) that bind phorbol ester tumour promoters and the lipid second messenger DAG (diacylglycerol), and show specific GAP activity towards the small GTPase Rac. This review summarizes our knowledge of the structure, biochemical and biological properties of chimaerins. Recent findings have established that chimaerins are regulated by tyrosine kinase and GPCRs (G-protein-coupled receptors) via PLC (phospholipase C) activation and… CONTINUE READING

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