Chimaeric analysis reveals role of Pdgf receptors in all muscle lineages

Abstract

Blood vessels originate as simple endothelial cell tubes. It has been proposed that platelet-derived growth factor B polypeptide (Pdgfb) secreted by these endothelial cells drives the formation of the surrounding muscular wall by recruiting nearby mesenchymal cells1,2. However, targetted inactivation of the Pdgfb gene3 or the Pdgf receptor β(Pdgfrb) gene4… (More)
DOI: 10.1038/ng0498-385

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