Children as participants in medical research.

@article{Grodin1988ChildrenAP,
  title={Children as participants in medical research.},
  author={Michael A. Grodin and Joel J. Alpert},
  journal={Pediatric clinics of North America},
  year={1988},
  volume={35 6},
  pages={1389-401}
}
The use of children in research raises the questions about proper justification, assessment of benefit in relation to risk, ability to consent, compensation, and the just selection of subjects. Although substantive and procedural standards have evolved, subpopulations of vulnerable children created new challenges and concerns.