Childhood trauma and psychosis: a critical review.

  title={Childhood trauma and psychosis: a critical review.},
  author={Sarah Bendall},
  journal={Acta neuropsychiatrica},
  volume={18 6},
Background: In this study, it was hypothesized that higher COMT activity as conferred by the COMT 158val allele leading to decreased norepinephrine and dopamine availability has a negative effect on antidepressant drug response in depression. Methods: A sample of 322 unrelated Caucasian patients with affective disorders (DSM-IV: major depression, n = 256, bipolar disorder, n = 66) was characterized and genotyped for the COMT val158met variant. Weekly Hamilton Depression Rating Scale (HAM-D… CONTINUE READING