Childhood-onset systemic lupus erythematosus: an update

@article{Borgia2015ChildhoodonsetSL,
  title={Childhood-onset systemic lupus erythematosus: an update},
  author={R Ezequiel Borgia and Earl D. Silverman},
  journal={Current Opinion in Rheumatology},
  year={2015},
  volume={27},
  pages={483–492}
}
  • R. Borgia, E. Silverman
  • Published 1 September 2015
  • Medicine, Biology, Psychology
  • Current Opinion in Rheumatology
Purpose of reviewThis is an update of the main studies published in the last year regarding biomarkers, advances in pathophysiology, lupus nephritis as well as outcomes and therapies in childhood-onset systemic lupus erythematosus (cSLE). Recent findingsSome progress in the pathophysiology of cSLE was made in the past year. Although biomarkers were studied in lupus nephritis and neuropsychiatric lupus, none of the proposed biomarkers was shown to be a significant improvement over current… 

Biomarkers in Childhood-Onset Systemic Lupus Erythematosus.

Impact of the longitudinal quantitative assessment of juvenile systemic lupus erythematosus severity on the disease outcome

TLDR
An early diagnosis combined with longitudinal quantitative assessment is a key determinant for an optimal management and a minimal damage development and contributes to the continuous evaluation of the disease state.

Pentraxin-3 levels are associated with vasculitis and disease activity in childhood-onset systemic lupus erythematosus

TLDR
Results support that PTX3 reflects active cutaneous vasculitis in cSLE and correlates with disease activity, and investigate its relation with diseaseActivity, damage, clinical features, laboratory parameters and medications.

Systemic Lupus Erythematosus: contributory factors and diagnosis

TLDR
Pregnancy outcome appears to be worse in people with SLE whose disease flares up during pregnancy, and treatment includes corticosteroids and anti-malarial drugs.

Anasarca as the initial symptom in a Japanese girl with Sjögren’s syndrome

TLDR
Elevated levels of serum C-reactive protein, ferritin and plasma D-dimer suggested that systemic inflammation caused anasarca by both decreased production of albumin and hyperpermeability associated with vascular endothelial damage similar to systemic capillary leak syndrome.

Evaluation of pulmonary artery pressure in patients with juvenile systemic lupus erythematosus (jSLE).

TLDR
Overall, PASP and mPAP were significantly higher in jSLE patients compared to healthy controls and Prospective studies with ethnically diverse cohorts could give more insight on the relevance of PAP and PHT in patients with jSle.

Cross-sectional study of plasma Axl, ferritin, IGFBP4 and sTNFR2 as biomarkers of disease activity in childhood-onset SLE: A study of the Pediatric Nephrology Research Consortium

TLDR
In childhood-onset SLE patients, plasma ferritin and Axl perform better than traditional yardsticks in identifying disease activity, either global or renal.

Stability of novel urinary biomarkers used for lupus nephritis

TLDR
RAIL biomarkers are stable following short-term storage at clinically relevant conditions following shipping on dry or wet ice exposure and addition of two freeze-thaw cycles, with excellent Spearman Correlation coefficients under all conditions.

Hepatitis A virus vaccination in childhood-onset systemic lupus erythematosus

TLDR
It is concluded that inactivated hepatitis A vaccine is safe and well tolerated in childhood-onset systemic lupus erythematosus patients, with no adverse events or increase in activity.

References

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TLDR
Novel biomarkers for cSLE include cell-bound complement activation products, some genomic profiles, and urinary proteins such as neutrophil gelatinase-associated lipocalin, monocyte chemoattractant protein-1, and others which can be used for monitoring disease activity and response to treatment.

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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