Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment.


OBJECTIVE The effect of clozapine on striatal morphology was examined in adolescents with childhood-onset schizophrenia. METHOD Eight adolescent patients with onset of psychosis before age 12 and eight matched comparison subjects had initial and 2-year follow-up brain magnetic resonance imaging scans. Basal ganglia and lateral ventricle volumes were measured. The patients were on a clozapine regimen during the 2-year interim. RESULTS Caudate volume was larger in the patients at the initial scanning, decreased in the patients between scans, and did not differ significantly between the patients and the comparison subjects at the second scanning. CONCLUSIONS Caudate enlargement in patients with childhood-onset schizophrenia who are taking typical neuroleptics appears to be secondary to medication exposure. Rescanning to examine basal ganglia morphology is indicated for these patients when they are taking an atypical neuroleptic.


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@article{Frazier1996ChildhoodonsetSB, title={Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment.}, author={Jean A. Frazier and Jay N. Giedd and Debra L. Kaysen and Kathleen E Albus and Susan D Hamburger and J Alaghband-Rad and Marge C Lenane and Kryss McKenna and Alan Breier and Judith L. Rapoport}, journal={The American journal of psychiatry}, year={1996}, volume={153 4}, pages={564-6} }