Childhood-onset schizophrenia: an open-label study of olanzapine in adolescents.

  title={Childhood-onset schizophrenia: an open-label study of olanzapine in adolescents.},
  author={Sanjiv Kumra and Leslie K. Jacobsen and Marge C Lenane and Barbara Illowsky Karp and Jean A. Frazier and Alicia K. Smith and Joshua Bedwell and Pauline E. Lee and Carl J. Malanga and Susan D Hamburger and Judith L. Rapoport},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  volume={37 4},
OBJECTIVE Olanzapine, a potent 5-HT2a/2c, dopamine D1D2D4 antagonist with anticholinergic activity, has a profile of known receptor affinity similar to that of clozapine. This pilot study examined the efficacy of olanzapine for treatment-refractory childhood-onset schizophrenia in eight patients who had received 8-week open-label trials. For comparison, data are included from 15 patients who had received 6-week open-label clozapine trials using identical rating instruments (largely by the same… CONTINUE READING
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