Childhood medulloblastoma: the paradigm shift in molecular stratification and treatment profile.

@article{Sadighi2012ChildhoodMT,
  title={Childhood medulloblastoma: the paradigm shift in molecular stratification and treatment profile.},
  author={Zsila S Sadighi and Tribhawan S. Vats and Soumen Khatua},
  journal={Journal of child neurology},
  year={2012},
  volume={27 10},
  pages={1302-7}
}
Medulloblastoma is the most common malignant brain tumor of childhood, accounting for nearly 25% to 30% of primary central nervous system tumors in children younger than 18 years of age. Risk stratification into low and high risk categories has been based on age of clinical presentation, extent of postsurgical residual tumor, and disease dissemination. The World Health Organization (WHO) in 2007 recognized 5 histological subtypes as classic, anaplastic, large cell, desmoplastic/nodular, and… CONTINUE READING