Childhood giant axonal neuropathy. Case report and review of the literature.

  title={Childhood giant axonal neuropathy. Case report and review of the literature.},
  author={R. K. Tandan and Benjamin W. Little and E S Emery and Paul F. Good and William W. Pendlebury and Walter G. Bradley},
  journal={Journal of the neurological sciences},
  volume={82 1-3},
Giant axonal neuropathy (GAN) is a rare autosomal recessive childhood disorder characterized by a peripheral neuropathy and features of central nervous system involvement. Typically seen are distal axonal swellings filled with 8-10 nm in diameter neurofilaments in central and peripheral axons, and intermediate filament collections in several other cell types. Many neurotoxins produce a morphologically similar neuropathy in humans and experimental animals. Defective nerve fiber energy metabolism… CONTINUE READING
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