Childhood and maternal infections and risk of acute leukaemia in children with Down syndrome: a report from the Children's Oncology Group

@article{Canfield2004ChildhoodAM,
  title={Childhood and maternal infections and risk of acute leukaemia in children with Down syndrome: a report from the Children's Oncology Group},
  author={K N Canfield and Logan G. Spector and Leslie L. Robison and Deann Lazovich and Michelle A. Roesler and Andrew F. Olshan and Franklin O. Smith and N A Heerema and Dorothy R Barnard and Cindy K. Blair and Julie A. Ross},
  journal={British Journal of Cancer},
  year={2004},
  volume={91},
  pages={1866 - 1872}
}
Children with Down syndrome (DS) are highly susceptible to acute leukaemia. Given the potential role of infections in the aetiology of leukaemia in children without DS, we investigated whether there was an association between early-life infections and acute leukaemia in children with DS. Maternal infections during pregnancy were also examined. We enrolled 158 incident cases of acute leukaemia in children with DS (97 acute lymphoblastic leukaemia (ALL) and 61 acute myeloid leukaemia (AML… CONTINUE READING

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