Childhood adversity and allostatic overload of the hypothalamic-pituitary-adrenal axis: a vulnerability model for depressive disorders.

@article{Wilkinson2011ChildhoodAA,
  title={Childhood adversity and allostatic overload of the hypothalamic-pituitary-adrenal axis: a vulnerability model for depressive disorders.},
  author={Paul Oliver Wilkinson and Ian M. Goodyer},
  journal={Development and psychopathology},
  year={2011},
  volume={23 4},
  pages={1017-37}
}
Childhood adversity is associated with increased risk for onset of depressive episodes. This review will present evidence that allostatic overload of the hypothalamic-pituitary-adrenal axis (HPAA) partially mediates this association. The HPAA is the physiological system that regulates levels of the stress hormone cortisol. First, data from animals and… CONTINUE READING