Childhood absence epilepsy: Genes, channels, neurons and networks

@article{Crunelli2002ChildhoodAE,
  title={Childhood absence epilepsy: Genes, channels, neurons and networks},
  author={Vincenzo Crunelli and Nathalie Leresche},
  journal={Nature Reviews Neuroscience},
  year={2002},
  volume={3},
  pages={371-382}
}
Childhood absence epilepsy is an idiopathic, generalized non-convulsive epilepsy with a multifactorial genetic aetiology. Molecular-genetic analyses of affected human families and experimental models, together with neurobiological investigations, have led to important breakthroughs in the identification of candidate genes and loci, and potential pathophysiological mechanisms for this type of epilepsy. Here, we review these results, and compare the human and experimental phenotypes that have… CONTINUE READING
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