Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype

@article{Huizinga2006ChildhoodMS,
  title={Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype},
  author={David H. Huizinga and Brett C. Haberstick and Andrew Smolen and Scott Menard and Susan E. Young and Robin P. Corley and Michael C. Stallings and Jennifer K Grotpeter and John K Hewitt},
  journal={Biological Psychiatry},
  year={2006},
  volume={60},
  pages={677-683}
}

Moderating role of the MAOA genotype in antisocial behaviour

TLDR
The analyses revealed consistent evidence of G x E interactions, such that those with the low-activity MAOA variant who were exposed to adversity in childhood were significantly more likely to report offending in late adolescence and early adulthood.

MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study

TLDR
Evidence is added that there is a stable G × E interaction involving MAOA, abuse exposure and antisocial behaviour across the life course, with those having the low-activity MAOA variant being significantly more likely to report later offending, conduct problems and hostility.

Maltreatment, MAOA, and Delinquency: Sex Differences in Gene–Environment Interaction in a Large Population-Based Cohort of Adolescents

TLDR
The results confirm previous findings of an interaction between the MAOA-VNTR polymorphism and self-reported maltreatment and boys with a short variant and girls with one or two long variants of the polymorphism showed a higher risk for delinquency when exposed to maltreatment.

Deviant Peer Affiliation and Antisocial Behavior: Interaction with Monoamine Oxidase A (MAOA) Genotype

  • Steve S Lee
  • Biology, Psychology
    Journal of abnormal child psychology
  • 2011
TLDR
There was evidence suggestive of a gene-environment interaction (G × E) where the influence of deviant peer affiliation on overt ASB was significantly stronger among individuals with the high-activity MAOA genotype than the low-activity genotype.

The interactive effect of the MAOA-VNTR genotype and childhood abuse on aggressive behaviors in Chinese male adolescents

TLDR
Aggressive behavior arising from childhood maltreatment is moderated by MAOA-VNTR, which may be differentially sensitive to the subtype of childhood malt treatment experienced, among Chinese adolescents.

Sex-Dimorphic Interactions of MAOA Genotype and Child Maltreatment Predispose College Students to Polysubstance Use

TLDR
The results indicate that PSU among college students is influenced by the interaction of MAOA and child maltreatment in a sex-specific fashion, and the highest number of substances were used by male students harboring low-activity MAOA alleles with a history of childhood emotional abuse.

MAOA genotype, family relations and sexual abuse in relation to adolescent alcohol consumption

TLDR
Results showed that the MAOA u‐VNTR, in interaction with psychosocial risk factors, such as the quality of family relations and sexual abuse, was related to high alcohol consumption among adolescents and supports the hypothesis that there is a sex difference in the G*E interaction.
...

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