Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype

  title={Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype},
  author={David H. Huizinga and Brett C. Haberstick and Andrew Smolen and Scott Menard and Susan E. Young and Robin P. Corley and Michael C. Stallings and Jennifer K Grotpeter and John K Hewitt},
  journal={Biological Psychiatry},

Moderating role of the MAOA genotype in antisocial behaviour

The analyses revealed consistent evidence of G x E interactions, such that those with the low-activity MAOA variant who were exposed to adversity in childhood were significantly more likely to report offending in late adolescence and early adulthood.

MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study

Evidence is added that there is a stable G × E interaction involving MAOA, abuse exposure and antisocial behaviour across the life course, with those having the low-activity MAOA variant being significantly more likely to report later offending, conduct problems and hostility.

Maltreatment, MAOA, and Delinquency: Sex Differences in Gene–Environment Interaction in a Large Population-Based Cohort of Adolescents

The results confirm previous findings of an interaction between the MAOA-VNTR polymorphism and self-reported maltreatment and boys with a short variant and girls with one or two long variants of the polymorphism showed a higher risk for delinquency when exposed to maltreatment.

Deviant Peer Affiliation and Antisocial Behavior: Interaction with Monoamine Oxidase A (MAOA) Genotype

  • Steve S Lee
  • Biology, Psychology
    Journal of abnormal child psychology
  • 2011
There was evidence suggestive of a gene-environment interaction (G × E) where the influence of deviant peer affiliation on overt ASB was significantly stronger among individuals with the high-activity MAOA genotype than the low-activity genotype.

The interactive effect of the MAOA-VNTR genotype and childhood abuse on aggressive behaviors in Chinese male adolescents

Aggressive behavior arising from childhood maltreatment is moderated by MAOA-VNTR, which may be differentially sensitive to the subtype of childhood malt treatment experienced, among Chinese adolescents.

Sex-Dimorphic Interactions of MAOA Genotype and Child Maltreatment Predispose College Students to Polysubstance Use

The results indicate that PSU among college students is influenced by the interaction of MAOA and child maltreatment in a sex-specific fashion, and the highest number of substances were used by male students harboring low-activity MAOA alleles with a history of childhood emotional abuse.

MAOA genotype, family relations and sexual abuse in relation to adolescent alcohol consumption

Results showed that the MAOA u‐VNTR, in interaction with psychosocial risk factors, such as the quality of family relations and sexual abuse, was related to high alcohol consumption among adolescents and supports the hypothesis that there is a sex difference in the G*E interaction.



Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment

  • B. HaberstickJ. Lessem J. Hewitt
  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2005
This work did not replicate a previous report that MAOA polymorphisms moderated the relationship between maltreatment and conduct problems, and there was, however, a non‐significant trend in the predicted direction.

Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients

Objective: Childhood maltreatment is a potent risk factor for subsequent aggressive and criminal behavior. A recent study suggested that the relationship between maltreatment and antisocial behavior

Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder.

This study replicates a recent report of a genotype-environment interaction that predicts individual variation in risk for antisocial behavior in boys and finds that low monoamine oxidase A activity increased risk for conduct disorder only in the presence of an adverse childhood environment.

Role of Genotype in the Cycle of Violence in Maltreated Children

A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A was found to moderate the effect of maltreatment, and it was found that Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems.

The importance of timing: The varying impact of childhood and adolescent maltreatment on multiple problem outcomes

Adolescent and persistent maltreatment have stronger and more consistent negative consequences during adolescence than does maltreatment experienced only in childhood.


Developmental psychopathology emphasizes the impact that early childhood maltreatment has on adolescent and early adult development. The life-course perspective, however, emphasizes more proximal

Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A.

Analytical results indicate that isolated complete MAOA deficiency in this family is associated with a recognizable behavioral phenotype that includes disturbed regulation of impulsive aggression.

Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder.

It is suggested that increased monoamine oxidase A activity is a risk factor for panic disorder in female patients because the longer alleles (3a, 4 and 5) were more active than allele 3.

The Short- and Long-Term Effects of Adolescent Violent Victimization Experienced Within the Family and Community

  • A. Fagan
  • Psychology, Law
    Violence and Victims
  • 2003
The results demonstrate that both types of violence have an immediate and sustained impact on criminal involvement, although the effect is somewhat stronger for nonfamily victimization, and for both types, the relationship tends to weaken over time.

Psychosocial sequelae of violent victimization in a national youth sample.

The findings suggest that substantial mental health morbidity in the general child and adolescent population is associated with victimization, and sexual assault was associated with particularly high levels of symptomatology.