Chikungunya virus arthritis in adult wild-type mice.

  title={Chikungunya virus arthritis in adult wild-type mice.},
  author={Joy Gardner and Itaru Anraku and Thuy Trong Le and Thibaut Larcher and Lee D. Major and Pierre Roques and Wayne A. Schroder and Stephen T Higgs and Andreas Suhrbier},
  journal={Journal of virology},
  volume={84 16},
Chikungunya virus is a mosquito-borne arthrogenic alphavirus that has recently reemerged to produce the largest epidemic ever documented for this virus. Here we describe a new adult wild-type mouse model of chikungunya virus arthritis, which recapitulates the self-limiting arthritis, tenosynovitis, and myositis seen in humans. Rheumatic disease was associated with a prolific infiltrate of monocytes, macrophages, and NK cells and the production of monocyte chemoattractant protein 1 (MCP-1… CONTINUE READING
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